DIM: Is It Really An Aromatase Inhibitor?
I mention Vitamin D on this website a lot, since it’s another substance which gets your testosterone up coming and going. You need it for testosterone production, and it helps decrease aromatization. The key to keeping aromatization in line is to inhibit the presence of aromatase in your body. As the name suggests, this enzyme is the key ingredient in the aromatization recipe that turns testosterone into estradiol. If you’re interested in hormone replacement therapy from a qualified team of professionals, fill out a contact form down below and someone will be in touch within 24 hours. If you think someone you know should read this, please share this article with them.
Aromatase in the Human Brain
Finally, some women may switch to an aromatase inhibitor after 2 or 3 years of tamoxifen, for a total of 5 or more years of hormone therapy. Research has shown that for postmenopausal women who have been treated for early-stage breast cancer, adjuvant therapy with an aromatase inhibitor reduces the risk of recurrence and improves overall survivalcompared with adjuvant tamoxifen (8). The similarity in the expression of aromatase in the brain of men and women is intriguing, considering that robust sex differences are presented by the enzyme in the brain of other species, including laboratory rodents.
AndrogenHacker
“If your estrogen levels dip below 20 pg/ml, your doctor may drop the dose to one milligram once a week, sometimes cycling it on and off for a couple of months,” Rambhatla says. Aromatase are a group of enzymes in the body that convert androgens and other hormones to Estrogens. Aromatase cytochrome P450 (P450arom) or estrogen synthase converts androgen c19 precursors in C18 estrogens.
- Over time, levels of the hormones testosterone and estrogen can become imbalanced in males, potentially causing health problems.
- You should be aware of what side effects could present; just because something is natural doesn’t mean it won’t have side effects.
- This often leads to higher testosterone levels, better energy, and improved physical performance.
- An aromatase inhibitor (in combination with ovarian suppression therapy) may be considered, however, for men who are unable to take tamoxifen for some reason.
Middle-aged sterile men that supplemented with 220 mg zinc (sulfate) daily for two had an average 250% increase in sperm count and 54% increase in total testosterone levels(the zinc supplement effectively restored fertility) 6. However, more clinical data is needed to confirm the impact of zinc supplements on estrogen levels in men. Less significant is your intake of carbohydrates and protein, however, an increased protein intake tends to lead to improved fat loss during caloric restriction and more muscle mass, in addition to better controlled blood glucose 45,46. Naturally, serum oestrogens levels decrease with a lowered body fat percentage too, as there has been less available fat to produce aromatase enzyme.
Hence, there remains an urgent need to evaluate long-term bone health data with the use of AIs in the elderly. Without that, long-term use of AIs cannot be recommended in obese and elderly men with hypogonadism. In this proof-of-concept trial, change in HOMAIR after 12 months of AI did not differ significantly from T replacement or placebo. The effects of the intervention on subcutaneous fat and adipokines were variable.
For more information, see the TNM Definitions section in Breast Cancer Treatment. In 1994, a University of Minnesota study looked at the impact of Luteolin on aromatase production, finding that https://grupovilarino.com/anavar-10-mg-omega-meds-effects-2/ it prevented its production in fat cells (source). This process is a necessary part of the systems which keep your body’s hormones in balance. But if things are out of balance it can lead to excess estrogen, especially as you age.
